Lab News

June 20, 2020

The Kanthi lab is moving to the National Heart, Lung, and Blood Institute of the NIH in Bethesda, MD!

Dr. Kanthi has been named a Lasker Investigator at the NIH, and will be building a translational vascular medicine research program much like we have been doing with our COVID-19 work.

More exciting and collaborative work to come!

May 15, 2020

COVID-19 CLINICAL TRIAL LAUNCH

Thanks to support from the Taubman Medical Research Institute, we are launching a clinical trial to test a safe, FDA-approved drug in COVID-19!


Read about the trial here

April 27, 2020

COVID-19 UPDATE - Progress is faster when teams collaborate!

1. Thanks to the Frankel Cardiovascular COVID Ignitor Grant and the Taubman Medical Research Insitute for supporting our COVID research.

We (Kanthi and Knight Labs) have identified a potential neutrophil biomarker in the serum of patients with COVID that may predict severity of infection. This was a tremendous multi-disciplinary effort between the Kanthi and Knight labs. Read more in this work published in JCI Insight last week.

Thanks to the journal and editors for a speedy review.


2. Dr. Kanthi wrote a commentary in JACC Basic & Translational Science with Dr. Aditya Sharma from UVA on a new way to study DVT in animals developed by Okano and colleagues.

March 29, 2020

COVID-19 UPDATE - Time to Roll Up Our Sleeves!

1. We are working at light speed to start a COVID Biomarker Research Study in collaboration with Dr. Jason Knight's lab. This will be the fastest one of our studies has gone from conception to execution.

2. We scoured the lab and donated supplies to Michigan Medicine for health care workers to use in patient care. Thank you to all health care workers - EMS to housekeeping to nurses and doctors! We will hunt for more supplies and ways to contribute.

3. We scaled down our wet lab three weeks ago to reduce possiblity of community transmission of COVID-19 in the pandemic.

4. Our team is working diligently from home to brainstorm new ideas, analyze data and write manuscripts. We meet virtually to review data and have our weekly journal club!

March 2020

Thanks to the NHLBI for R01 funding of our lab's research on inflammasome activation in venous thrombosis! Congratulations to our lab team and our collaborators.

We're eager to (continue) moving this work forward to develop new insights and treatments in DVT.

November 2019

We are fortunate and excited to receive new grant funding from the Falk Medical Trust in collaboration with Dr. Lola Eniola-Adefeso. This Catalyst Award will support development an innovative technology in vascular disease.

Read more about Dr. Lola Eniola-Adefeso at: https://en.wikipedia.org/wiki/Lola_Eniola-Adefeso

October 2019

Our good friends in Dr. Nadia Sutton's lab published an interesting paper on the age-dependent effects of CD73 on atherosclerosis. CD73 protects middle-aged mice from atherosclerosis, but it increases plaque dramatically as mice get older. Their worked earned the cover of ATVB!

Check it out: https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313002 And the cover!!!----------------------->

August 2019

The lab received two new grants from the Biointerfaces Institute at the University of Michigan!

These grants are to help us develop novel technologies in cardiovascular disease by bringing together cardiovascular and engineering investigators. Exciting times ahead!

We're excited to collaborate with and learn from these talented scientists:

Dr. Lola Eniola-Adefeso in Chemical Engineering





Dr. Anish Tuteja in Materials Science and Engineering







Dr. Geeta Mehta in Materials Science and Engineering

July 2019

Raymond and Kinsey get their white coats as they start medical school at the University of Michigan! Looking forward to seeing them in the hospital with patients @umichmedicine

June 2019

1st Annual Lab Olympic Games were held June 19. We brought together 5 cardiovascular labs to test their skills in Feats of courage, pipetting, steady hands, and memory!

In the end, "Team Mitochondria" won the Games, followed closely by "The Calcium Wave" and "Team Macrophages".

May 2019

Some of the lab attended the Gull Lake Hypertension Symposium and presented their work. While we don't study hypertension, lots of good vascular biology learning and camaraderie with other Michigan investigators in this beautiful space.

Here's a pic with some Michigan Medicine friends!

May 2019

Brianna presented her research on endothelial stretch physiology at the Michigan Medicine Internal Medicine Research Symposium! Bri's message "Endothelial transfection is difficult. Yet we persevere!"

May 2019

Congratulations to current lab member Raymond Zhao, and lab alumni Kinsey Vear who have both chosen to attend the University of Michigan Medical School. We're so proud! They're both very talented, with brilliant careers ahead!

April 2019

Excited to announce a manuscript! Congratulations to Vinita Yadav, Liguo Chi and the team on a terrific manuscript accepted for publication in the Journal of Clinical Investigation. In this study, we uncovered inflammasome activation as a novel, signaling pathway that fuels venous thrombogenesis. We found that CD39 restricts neutrophil and inflammasome activation, offering protection from DVT. We're glad to have such wonderful collaborators who helped with this project.

This research is featured on the cover of JCI (July 2019)

Open access article available here


April 2019

Excited to announce a collaboration manuscript! We have a research paper in collaboration with Jason Knight ( @jasonsknight) published in Nature Communications. Collaborating with Jason and his Rheumatology lab, we found the adenosine 2A receptor functions as a brake on antiphospholipid antibody-mediated venous thrombosis. Thanks for collaborating with us, and congratulations to Ramadan Ali who is 1st author on this publication!

Open access article available here

More information about the Knight Lab

April 2019

Congratulations to current freshman Jessica Wang on being awarded an LSA Summer Fellowship to continue her research this summer on endothelial function in DVT!

March 2019

Excited to announce a manuscript! Glad to have our research published in ATVB this month. In this paper, we discovered an enzyme on the surface of vascular cells (CD39) that directs an anti-inflammatory and anti-thrombotic program in venous thrombosis. There is some great micro-array data in this paper.

Open access article available here

More to come on this soon...

February 2019

Congratulations to Raymond and Kinsey, both accepted to top 5 medical schools! Decisions pending!

January 2019

Welcome Gillian Cady as the newest member of the lab! This is Gillian's second time at U-M. She has an interest in immunology and learning new niches in science, having spent time at Roswell Park (NY) and Wayne State (Detroit) before joining us.

June 2018

Congratulations to Brianna Giese on being awarded a Stamps Summer Research Fellowship! Brianna will spend the summer studying mechanotransduction in endothelial cells.

December 2018

Congratulations to Raymond on graduating early with his Bachelor's degree in Biomedical Engineering from the University of Michigan . Raymond is going to stay on in the lab to move his project forward until he starts medical school in the Fall.

November 2018

Congratulations to Alison Banka on her oral abstract presentation during the Sol Sherry Distinguished Lecture Session at the American Heart Association Scientific Sessions this November in Chicago!

October 2018

Raymond Zhao getting his "science fix". He won a record for smiling through all 288 tubes of pipeting!

October 2018

Sunrise to mid-day - A nice view to work from...

September 2018

Welcome to Jessica Wang and Nishant Chava, two new undergraduate students joining the lab!